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We’re all familiar with the feeling of sweaty armpits after a hot yoga class, or whatever activity spikes our body temperature. A lesser-discussed sweaty area, however, is that of the hands. Damp handshakes, soggy assignments, and puddles on your desk can be problematic and embarrassing.
The most common first line of defense against excessive sweat is antiperspirant. Keep reading for our picks for the best antiperspirant for hand sweat.
This post was published in July 2020, and updated in 2020, 2021, 2022, 2024, 2025.
While sweaty hands can be caused by many factors, the effects are always the same. You’ve most likely heard references to sweaty palms when somebody feels nervous or on edge. It’s a common side effect of situational anxiety or stress. Issues with thermoregulation and emotional stress can also act as catalysts for sweaty hands.
More serious cases of excessive hand sweat may be the result of a medical condition called palmar hyperhidrosis. In general, people diagnosed with hyperhidrosis sweat as much as four to five times more than the average person without provocation.
For those wondering if you can really use antiperspirant on your hands, the answer is a resounding yes! Antiperspirants typically contain aluminum-based compounds that combat sweat by temporarily blocking sweat glands. This means antiperspirants can be applied to most areas of the body (not just the underarms) with similar results.
With that said, there are products specifically designed with hand sweat in mind. Usually, antiperspirants for hands give the best results when applied at night to clean and dry skin. This gives the formula a chance to work its magic overnight and provide maximum protection the next day.
Antiperspirant for hand sweat also comes in gel form, as with Duradry Antiperspirant Gel. The unique formula combines aluminum chloride and salicylic acid to produce effective results that tackle excessive sweating. This is one of the best clinical-strength antiperspirants for hands, recommended by dermatologists. Because of its strength, apply it to a small area first to test for skin sensitivity. (Buy on Amazon)
Like Gamer Goo, this product is designed to improve your grip when you’re dealing with sweaty hands. Dry Hands isn't sticky or greasy and leaves no powdery residue on your hands. It lasts for hours and only takes a small amount to give you the best protection. This product can improve activities when a dry grip is essential, like golf, weight lifting, or gaming. (Buy on Amazon)
An effective antiperspirant for palms is Carpe Antiperspirant Hand Lotion. The quick-drying formula is specially designed to eliminate sweat while moisturizing hands. Developed by dermatologists, the lotion is clinically proven to be effective in managing palmar hyperhidrosis. For best results, apply a pea-sized amount at night and again in the morning. (Buy on Amazon)
SweatBlock's fast-drying antiperspirant hand lotion is specifically designed to combat excessive hand sweating. This dermatologist-tested, non-greasy lotion offers immediate drying effects and long-lasting sweat protection. Apply it twice daily for effective control of problematic hand sweating. Confidently shake or hold hands without concerns about clammy hands. (Buy on Amazon)
SweatBlock Antiperspirant Lotion for Hands & Feet is the best hand antiperspirant for excessive sweating associated with palmar hyperhidrosis. With only a pea-sized amount, you’ll have full protection with this clinical strength formula. The added aloe helps to keep skin moisturized. The antiperspirant doubles as a foot lotion if you experience sweating in that area, too! (Buy on Amazon)
Are you struggling with sweat in other areas, too? If so, Ejis sweat proof boxer briefs and undershirts (available from our shop or on Amazon) may be just what you need to prevent sweat stains. Our sweat proof basics are made of premium fabric fused with odor-fighting silver and an ultra-thin waterproof layer to protect your butt, back of the legs, crotch, back, and armpits.
Ejis, Inc. is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking toamazon.com. Some links on this page provide us with a commission at no additional cost to you.
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