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The 14 Best Clinical Strength Antiperspirants & Deodorants in 2022

March 25, 2021 6 min read

best clinical strength antiperspirant

It’s 11:30 in the morning, and you already feel your sweat seep through your shirt… even though you applied antiperspirant right after your shower. Does this scenario sound familiar? If so, you may need to switch to a stronger antiperspirant specially designed for people who excessively sweat. Keep reading for some of the best clinical strength antiperspirants on the market.

Sweat is an essential mechanism used by our bodies to cool us down and regulate body temperature. However, some people sweat excessively regardless of the temperature or their level of physical exertion. This is typically caused by a medical condition called hyperhidrosis. One of the easiest ways to treat hyperhidrosis without seeing a doctor is to use clinical strength antiperspirants, like the ones we've highlighted in this article.

This post was originally published in April 2020, and was updated in March 2021 and January 2022.

How To Use Clinical Strength Deodorant or Antiperspirant

One of the most important things to know when using a clinical strength antiperspirant or deodorant is how to properly use it. Here are some tips to get the best out of your deodorant.

  • Apply the deodorant or antiperspirant to your underarms and areas where you sweat the most from, or where visible sweat marks appear.
  • Experts advise you to apply the product to clean skin at night instead of in the morning, which is the popular practice. This gives the active ingredients the necessary time to properly absorb and block your sweat pores.
  • Use only the recommended amount to avoid skin irritation.
  • Consider shaving or trimming your armpit hair to give the product a chance to make direct contact with your skin. With less hair under your arms, there is less chance for sweat to collect and mix with bacteria.

Now let’s get into the crux of this article to answer the probing question: what are the best clinical strength deodorants and antiperspirants?

1. Arm & Hammer UltraMax Antiperspirant Deodorant

Starting off the list of contenders for the best deodorant for hyperhidrosis, Arm & Hammer’s UltraMax Antiperspirant Deodorant is an excellent option in regards to function and price. It provides maximum strength all-day protection against sweat. This invisible solid goes on clear so it won’t stain clothing or leave a residue on your skin. It is also unscented, so you can wear your favorite cologne without worrying about competing scents.  (Buy on Amazon

2. Certain Dri Everyday Strength Antiperspirant Deodorant

Certain Dri brings another excellent product to the list with its Everyday Strength Antiperspirant Deodorant. This clinical strength deodorant for excessive sweating, or hyperhidrosis, provides effective sweat and odor protection all day long. The active ingredient in this formula is 20% Aluminum Zirconium Complex to block sweat. It is also safe to apply to other areas of your body that may be prone to sweat. For best results, apply at night to clean and dry skin. (Buy on Amazon)

3. Certain Dri Prescription Strength Clinical Antiperspirant

Certain Dri offers sweat protection for up to 72 hours. The active ingredient in this clinical strength antiperspirant works best when left on underarms overnight to work its magic. Just a few strokes applied to dry skin will help avoid irritation. It is formulated to not wash off the next day, even when showering. But feel free to apply an extra layer in the morning for added protection and freshness. (Buy on Amazon

Clinical-Strength Antiperspirants and Deodorants - Man Applying to Underarm

4. Degree Men Clinical Antiperspirant & Deodorant

When considering the best men's deodorant for excessive sweating, check out Degree Men Clinical Antiperspirant & Deodorant. It is Degree’s most powerful product to combat excessive sweat. This antiperspirant deodorant also features MotionSense technology, which is motion-activated odor protection that lasts throughout the day. It works best when applied at night to allow it to work while you sleep. (Buy on Amazon)

5. Dove Men+Care Clinical Antiperspirant Deodorant Stick

One of the best prescription strength antiperspirants designed for men is the Dove Men+Care Clinical Antiperspirant Deodorant Stick. This compact deodorant delivers powerful protection against wetness and odor for up to 48 hours. It has a crisp scent to keep you feeling fresh all day. To protect against irritation, it’s designed with moisturizing technology that is gentle on your skin. The antiperspirant can be applied in the morning; but for the best protection, apply at night. This allows the formula to set in. (Buy on Amazon)

6. Dr. Sweat Antiperspirant Deodorant Pads for Excessive Sweating

Next up on the list of best clinical strength antiperspirants is Dr. Sweat’s deodorant pads. The pads are pre-soaked with an alcohol and fragrance-free deodorant formula, clinically proven to reduce sweat for up to 7 days. Each pad contains the correct dosage and coverage. Press or pat a pad onto freshly washed and towel-dried armpits before going to bed for maximum protection. To avoid irritation after shaving, wait between 24-48 hours to apply. (Buy on Amazon)

Clinical-Strength Deodorants & Antipersprants - Man Applying to Underarm

7. Gillette Clinical Strength Antiperspirant Deodorant

Gillette Clinical Strength Antiperspirant Deodorant blocks sweat and fights odor for up to 48 hours. The formula contains over 10,000 odor-fighting molecules to neutralize odor, instead of masking it like other products. Coupled with 6.25% aluminum chloride for wetness protection, this product makes its mark as the best deodorant for heavy sweaters. It is a soft solid application, so it goes on dry and stays dry. (Buy on Amazon)

8. Maxim Prescription Strength Antiperspirant & Deodorant

Maxim’s Prescription Strength Antiperspirant & Deodorant provides maximum protection with a few simple half strokes of the roll-on applicator before bed. You can also apply your regular deodorant as normal after showering in the morning. To combat the effects of hyperhidrosis, Maxim provides dryness for up to 7 days with its alcohol-free, prescription strength formula. (Buy on Amazon)

9. Odaban Antiperspirant Spray

Odaban Antiperspirant Spray comes in easily transportable 30 ml bottles and can be used on most areas of the body. Its pump spray application contains the precise amount of antiperspirant formula to avoid over-spraying that can lead to irritation. The antiperspirant is designed to feel gentle yet effective, with dryness lasting up to 24 hours. The full effects should be noticeable after a few days of usage. (Buy on Amazon)

Clinical Strength Antiperspirants & Deodorants - Man Spraying on Underarms

10. Right Guard XTreme Defense Antiperspirant Deodorant

Right Guard tackles body odor for 72 hours with its advanced odor protection technology. XTreme Defense Antiperspirant Deodorant offers protection to prevent sweat with more sweat blockers in its new 5-in-1 formula. The XTreme high-performance formula is available in a stick or gel. It also won’t stain or discolor your clothes. (Buy on Amazon

11. SweatBlock Clinical Strength Antiperspirant Wipes

SweatBlock is a clinical strength antiperspirant that comes in the form of wipes. Once in regular use, the effects can keep you dry for up to seven days. For first time users, use for four consecutive days and then apply as needed. The wipes are more effective when applied to clean skin at night before bed. SweatBlock antiperspirant wipes are scented and individually packaged. (Buy on Amazon)

12. SweatStop Antiperspirant

As stated in the name, this antiperspirant aims to stop excessive sweat, helping you to manage hyperhidrosis. SweatStop has a range of antiperspirant products for different areas of the body including the underarms, hands and feet, forehead, and head. Application methods vary among roll-ons, sprays, and lotion; the intensity of each is noted on the packaging to help you determine the best formula for your needs. SweatStop also offers antiperspirants for sensitive skin. The range of products and formulas makes this brand one of the best prescription strength antiperspirants. (Buy on SweatStop website)

best prescription strength antiperspirant

13. Vanicream Clinical Strength Antiperspirant Deodorant

Vanicream is another contender for the best deodorant for hyperhidrosis in the form of a balm. This combo antiperspirant deodorant product is specially designed for sensitive skin. It’s clinical strength formula contains Aluminum Zirconium Trichlorohydrex Gly 20% to provide 24-hour protection from sweat. It is free from fragrance, dyes, parabens, and other preservatives. It glides on smooth and dry. (Buy on Amazon)

14. ZeroSweat Original Clinical Strength Antiperspirant

ZeroSweat is one of the best clinical strength antiperspirants to combat hyperhidrosis without resorting to costly medical procedures. This roll-on antiperspirant should be applied at night, so you can start your day with dry armpits. ZeroSweat ensures dryness for up to 7 days with one bottle lasting for up to 3 months. (Buy on Amazon)

If your current antiperspirant or deodorant has left you anything but dry, try out one of these clinical strength antiperspirants and clinical strength deodorants designed to combat excessive sweating. Make sure to follow the product's application guidelines to get the best results. 

To ensure all-day protection, wear an Ejis sweat proof undershirt. (Buy from our shop or on Amazon.) Our sweat proof undershirts are designed to protect your shirts from sweat marks and stains. They are also infused with real silver to fight odor-causing bacteria.

Ejis, Inc. is a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for sites to earn advertising fees by advertising and linking to amazon.com. Some links on this page provide us a commission at no additional cost to you.

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